A cruise around the British isles in August (to attend the Edinburgh Tattoo), combined with a TA back to the US with stops in Iceland and Greenland. (Can you tell I've thought about this one?)
A cruise (currently offered by Voyages to Antiquity) that goes from Sri Lanka to India, then spends 5 days in India to see the highlights of the Golden Triangle.
A Black Sea cruise.
Rome. By all means, Rome. [Audrey Hepburn, Roman Holiday]