There's a shuttle service that runs from MCO to the Villages, not sure what the cost is. Maybe take a shuttle from FLL to MCO and then switch?
Probably just as easy and cost efficient to rent a car one-way. Be aware that many of the rental car places around the Villages are franchises and won't accept a one-way drop off, so do your homework and double check.
August 2002--Disney Magic Eastern Caribbean
October 2005--RCCL Mariner Western Caribbean
October 2011--Disney Dream Bahamas
June 2012--Windstar Wind Surf Back-To-Back, Rome to Venice to Athens
April 2014--Paul Gauguin to French Polynesia
Three weeks in Europe (two on a ship) with a 20" roll aboard and a tote bag--packing list here.
My all in a 20" wheeled bag for a warm weather cruise packing list here
20" rolling bag packing list for two weeks in a cool/cold climate here.