Panama Canal Cruise in December
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Typical Panama Canal "season" is Oct 1 to mid May. Cruise lines don't go thru in the other months. As April/May is Spring, it might be calmer then, but no promises.
The Canal is an awesome special event. I wouldn't (and we have sailed the Canal 3 times) put a rough sea in front of going to the Canal.
Have done the full transit of the Canal several times. It is a sight to see.
We have experienced all kinds of weather in the Pacific and at different times of the year.
Since weather is unpredicable -- book the cruise and go and enjoy the canal.
Stopped counting a few years ago -- have done over 140 cruises.