AgentDelta

Speaking as someone who grew up in Fort Worth with relatives in San Antonio, my recommendation would be to not limit yourself to the major freeways when planning driving routes. Highway 281 is my preferred pathway between Fort Worth and San Antonio, and I generally find it a more pleasant experience than driving on Interstate 35, though I have friends who would disagree with me. I generally find that there's less traffic on the smaller roads like 281 than there is on 35, and the route is more scenic overall. The downside is that there are fewer lanes (oftentimes just one lane in each direction, so if you get stuck behind a slower driver, you may have to wait awhile to get to the next area with a passing lane) and you'll encounter traffic lights and significant variations in the speed limit as you pass through the various small towns along the way. Ultimately the choice comes down to your preferences and what you're most comfortable with; I just wanted to throw it out there as an option.