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Our first time cruise, in September 2008, was on Oceania's Nautica, Istanbul to Athens. Oceania is a lovely line with small ships (684 passengers max). Our third Oceania cruise will end in mid-May 2010 in Barcelona.
Celebrity do 10 and 11 night eastern Mediterranean cruises out of Rome. This year they've been on one of their very latest ships, Celebrity Solstice; next year I think they're using a sister ship, Celebrity Equinoxe. Excellent ships, and itineraries to die for.
My Fiance and I are booked on the Ruby Princess july 2010 - Bacelona, Monte Carlo, Florence/Pisa, Rome, Naples, Mykanos, Istanbul, Ephesus, Athens and Venice... It's going to be amazing... good luck do lots of research